Worldwide, nearly 6% of people experience depression. Many of them continue taking antidepressants after achieving symptomatic improvement, among other reasons to prevent a relapse of depression. An international team of researchers investigated which antidepressants, if any, can not only get patients well but also keep them well (sustained response).
Comparing long-term effectiveness
This study utilized evidence from 115 previously conducted randomized clinical trials, involving more than 30,000 participants in total. Researchers compared 20 antidepressants with one another and with the best-known antidepressant, fluoxetine. Results suggest that antidepressants can indeed keep people well during long-term use as well. Moreover, the
